Two sample MR report
HLA-A_Monocyte (Mono) against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 17 | 0.0752553 | 0.0552075 | 0.1929521 |
| Weighted median | 17 | 0.0662303 | 0.0089076 | 0.0000000 |
| Inverse variance weighted | 17 | 0.0638016 | 0.0067614 | 0.0000000 |
| Simple mode | 17 | 0.0680922 | 0.0148484 | 0.0003045 |
| Weighted mode | 17 | 0.0676185 | 0.0146915 | 0.0002942 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 2.069491 | 15 | 0.9999628 |
| Inverse variance weighted | 2.113189 | 16 | 0.9999849 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0051475 | 0.0246246 | 0.8372287 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0003886 | 1e-07 | TRUE | 0.0640801 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
